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The Links Between Surgical Mesh Complications and the Development of Autoimmune Diseases

nonie wideman 300

Nonie Wideman, Contributor

Mesh Medical Device News Desk, July 21, 2017 ~  Canadian, Nonie Wideman, is a survivor of medical complications from synthetic medical mesh. 

She has spent over 15 years advocating for children and families, over twelve of them as a specialized care provider teaching coping and life skills.  Wideman turned the skills on herself after what she calls a disastrous experience with pelvic mesh implant failure and rejection.

Wideman says, “I had to recognize the problem, set goals to address the problem, and evaluate the effectiveness of my plan to deal with the problem.”

“I began relentlessly researching the “what the hell went wrong?

“It appears the “what the hell went wrong” question was largely ignored, unrecognized, and minimized in the medical community and buried by manufacturers of synthetic medical mesh whom I feel definitely  patted themselves on the back, for their part in improving quality of life for people having issues with prolapses, hernias and incontinence.

“Research revealed a lack of long term studies regarding the safety and reliability of medical mesh implants, the lack of follow up with patients receiving the aforementioned mesh products, lack of understanding by the medical community that they had regarding the rates of failure, the cause of failure, and the consequences of prolonged and chronic exposure. 

“I wish to challenge all my readers to question the use of synthetic medical mesh and ask for accountability from those who profited from the sale of these products at the expense of a significant number of patients living in the aftermath of synthetic medical mesh degradation and implant failure. With knowledge and truth we can join together to advocate for safety before profit.  I hope to empower people to demand honest answers and demand change.”

Mesh removed from LR after 3 months

Mesh removed from LR after 3 months

 

The Links Between Surgical Mesh Complications and the Development of Autoimmune Diseases

by Nonie Wideman, April 2013

Background

When researching mesh complications, if one were to listen to the most knowledgeable experienced people on the subject, one would not be listening to doctors or mesh manufacturers. To know exactly what is going on it would seem prudent to first talk to, and listen carefully to, the women implanted with polypropylene meshes for prolapse (POP), stress urinary incontinence (SUI) and listening to men and women with mesh hernia repairs. In defense of their own health, to advocate for skilled medical intervention to reduce pain and gain back quality of life, they have had to research to find answers as to why they hurt, why doctors think their pain is anything but mesh related, why they are sick, why their complications are hard to diagnose, and why doctors are reluctant to diagnose what is obvious to women and men with computers, internet and Google skills.

It is sad when patients have done more research than doctors.

Listening to the women with first-hand knowledge of transvaginal mesh complications, one thing is being made very clear by women; not enough attention is being paid to the systemic injury of mesh complications.  When listening to hernia patients, men and women are saying mesh complications affect your whole body, not just your abdomen.  According to Jonathan Blac (1984):

Evaluation of the host response to implanted biomaterials usually focuses on the implant site tissue response. This may lead to erroneous conclusions in the same way that examination of battles outside of their historic context does. A broader view discloses a variety of possible and actual systemic effects of carcinogenic, metabolic, immunological and bacteriological nature. Recognition of these effects in patients is hampered by a lack of epidemiological studies (19).”

Researching patients found they were not alone with their questions or symptoms. Patients like me discovered they could be considered by the medical community as high responders to medical mesh. In other words, we are all the population of patients experiencing chronic foreign body reaction to synthetic mesh implants. These synthetic meshes mentioned are predominately constructed of polypropylene or similar polymeric constructs. To break it down in simpler terms we all found that hypersensitivity to foreign body implants was, and is, the common denominator among us.   You might say for simplicity‘s sake we high responders are all “allergic” to the materials doctors implanted in us.

Foreign Body Response 

With the recent trials over the injuries caused by the controversial transvaginal implants, it becomes very evident that research into the long-term effects of polypropylene in human bodies is, as I have discovered, is almost non –existent.  I say “almost “, because there may be some study somewhere I have missed or others have missed that would enlighten us all. Alas, I have not found long-term studies that show what to expect with controversial synthetic meshes 3, 5, or 10 years into the future. Personal experience and research however indicates that complications may present with mesh implants as long as the implant remains in a live body.

With the new emerging information from the FDA that indicates complications rates to be higher than predicted or thought acceptable, for benefit to risk ratios, it appears more scrutiny is needed, and was needed.  Scrutiny comes late, and comes at the expense of patients’ health (5).

When synthetic mesh is surgically placed in your body, if your body is over sensitive, it matters not how skilled the surgeon is or unskilled he is at placing mesh, when it is the properties of the mesh and the body’s ensuing expected foreign body response gone awry that causes oxidative processes in the body to try degrade the foreign body enough so that cells can “eat” or dispose of the foreign matter that it can’t push out like a puss surrounded splinter. That oxidative process of chronic foreign body response has been proven to degrade polypropylene (7).

Fallen urethra and bladder, Windsor Urology UK

Fallen urethra and bladder, Windsor Urology UK

Polypropylene  mesh does not remain inert when  constantly attacked by  the oxidative processes of Foreign Body Response (12).( Should mesh actually ever have been considered inert in the first place as it is recognized by the human body as a foreign body as soon as it is implanted? )

Prolene Mesh

Degradation products of polypropylene  are  Alkyl radical, Alkoxy radical ,Peroxy radical and Hydroperoxide (1).   Note that these degradation products are free radicals, and they are considered toxic. If polypropylene has been treated with other surfactants to help dye fixation, as in blue dyed medical mesh, or treated with chemicals for sterilization because heat sterilization damages the mesh, then there are other degradation products to worry about.

Polymeric materials have long been identified as leaching estrogenic mimicking chemicals that are known to make cancer cells multiply; for example blue polypropylene piperettes used in lab experiments were found to be the source of experiment contamination in lab research. Women are wondering about nonylphenol leaching out of meshes and its estrogenic role in enabling cancer.

Scientists know polypropylene degrades under oxidative stress. Did no one think to test what chemicals could leach out and cause toxic chaos inside of peoples’ bodies? You would think because the implants were designed to be permanent, substantial testing would have occurred before marketing such medical devices. Substantial testing was not done (16).

Where am I going with this?

Systemic Storm

I am listing the ingredients of a recipe for autoimmune disease to develop.  It is a recipe for a systemic storm. It is a storm that also can predisposes one to cancer.  Predisposition for higher rates of cancer after mesh complications, is a subject deserving of an article all of its own. This article’s purpose is to draw attention the fact that there appears to be a high rate of autoimmune disorders in the population of women with chronic FBR that has caused implant failure and degradation.

I took a survey of patients with medical mesh complications that validated my suspicions and the suspicions of other patients. Many thanks go out to those who took the survey in order to  get a real snapshot of what the unrecognized systemic diseases are that mesh complication patients are dealing with, seeking validation for, and seeking skilled medical intervention for. I will share survey information at the conclusion of this article.

#1  Ignorance: No Biocompatibility Tests

I draw your attention back to the recipe for a devastating storm.  The number one ingredient in this systemic storm is ignorance. Doctors appear to have no tests to predict hypersensitivity to polypropylene in candidates for synthetic mesh implants.   Hypersensitivity (which may be a genetic predisposition or an acquired condition) should be a contraindication for a patient to be implanted with a synthetic material known to cause an inflammatory response, just as having an underlying autoimmune disease is a contraindication for mesh implantation according to some mesh manufacturer’s instructions for physicians (13).  That contraindication warning for surgeons makes me wonder what manufacturers really knew about the connection between FBR and autoimmunity and implant failure or success and failed to share with physicians and surgeons.

#2     Foreign Body Response

The second ingredient for a harmful systemic storm is a combination of the short term acute inflammation of FBR that usually decreases after thirty days from when the mesh is implanted, preceded by decreasing low grade chronic inflammation thereafter. (2)  However decreasing FBR is not always the outcome. Women with synthetic mesh implant complications have learned the hard way, that for women with mesh complications and implant failure, FBR does not decrease but increases, causing distressing cycles of burning sensation and pelvic cramping pain that many women say exceeds the pain of child birth and never ends. According to an article by a cancer treatment centre (3) “inflammation can become chronic if the cause of the inflammation persists, or because of deregulation in the control mechanisms responsible for shutting down the inflammation process.” Cancer researchers know there are links between chronic inflammation and cancer development (17, 18 ).  Autoimmune researchers know there are links between autoimmune disease development and chronic inflammation (23 ). Some surgeons know there is a link between implants and autoimmune disease development (14).

# 3     Chronic Infection

Now the 3rd ingredient is  a hit and miss in this recipe .  It is like an optional ingredient you would never want .That ingredient is chronic infection. Many patients with mesh complications have chronic infections, infections safely hidden in mesh structures too small for “good guy” cells to go in and attack bacterial infection.

Prof. Garth L. Nicolson states in his article Autoimmune Illnesses and Degenerative Diseases, “chronic infections play an important role in autoimmune and degenerative disease, along with genetic predisposition and immune dysfunction (22).” Nicolson also states infection could be the cause of autoimmune disease or a cofactor.

Reading the study,  Localized Immunosuppressive Environment in the Foreign Body Response to Implanted Biomaterials  by  David M. Higgins,* Randall J. Basaraba,* April C. Hohnbaum,* Eric J. Lee,* David W. Grainger,† and Mercedes Gonzalez-Juarrero , you become more aware of the serious harm of chronic infection and implant failure. According to these researchers “It is estimated that at least 20 million people in the United States have a biomaterial device implant. Implant device failure or implant-associated infections can have disastrous consequences for the implant device function and the host. Although the risk of implant-associated infections is small (1 to 7%), these infections are associated with considerable morbidity, expensive health care, and prolonged antibiotic therapy.2 The medical and surgical cost of treating certain device failures or implant-associated infections can average up to $50,000 per patient.3,4 These significant burdens and the increasing use of biomaterial implants in a myriad of medical applications warrants a clear understanding of the immune response to these materials (15 ) .”

So now we have recognized the following ingredients for a health disaster.

#1) hypersensitivity undiagnosed

#2) chronic inflammation causing degradation of mesh

#3) chronic infection.

 

#4   Chemical Insults

Now let’s add the 4th ingredient to the systemic storm recipe. Let’s add chemical irritation and insult. One product of the body’s attempt to break down polypropylene  via peroxide  (hydrogen peroxide produced by the body) is the dangerous Hydroxyl radical.  Life Extension Magazine published a report in 1995 on the Hydroxyl  radical. It was stated “the uncontrolled action of hydroxyl radicals the most damaging free radical by far can have devastating effects with the body.”

Consequences of hydroxyl can be seen in many diseases such as atherosclerosis, cancer and neurological disorders (4).  To add to the evidence that degradation  of polypropylene releases damaging hydroxyls note the quote from S. A. M. Ali, P. J. Doherty, D. F. Williams*Article first published online: 10 MAR 2003.

Prolene mesh and particles

Degradation is an essential factor in polymer biocompatibility. The physiological environment of the human body can be aggressive to polymers. Most implanted polymers suffer degradation and the kinetics and mechanisms of the processes can be significantly affected by various biologically active species, especially enzymes, lipids, peroxides, free radicals, and phagocytic cells. Iron enhances the toxicity of oxygen free radicals. Superoxide and hydrogen peroxide can interact to form the very toxic hydroxyl radical in the presence of iron. The data have shown that the hydroxyl radical is likely to be one of the main causes of polymer degradation in implantable devices. “

I could go on and on about the damage of free radicals but the point again is once again about inflammation; inflammation increased by chemical irritation. Inflammation is heightened by the reaction of damaged tissues surrounding the implant, tissues subjected to the peroxide attack against the implant material. Inflammation, chronic inflammation, has long been recognized as being a cause of diabetes, a cause of heart disease and a symptom of autoimmune disease. Perhaps more research should be done to address the fact that inflammation may not only be a symptom of autoimmune diseases but in fact be the cause of an autoimmune disease.

Lupus is one of the very scary autoimmune diseases some women are being diagnosed with after mesh implantation, after suffering months if not years of chronic pelvic inflammation from FBR to synthetic mesh. Many other autoimmune diseases are being diagnosed and suspected in this cohort of women, and in the population of hernia patents experiencing chronic FBR.  Read the following abstract regarding Lupus by Zafar Rasheed, , Rizwan Ahmad, Naila Rasheed and Rashid Ali (2007)

“Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with autoantibodies as a near universal feature of the disease. Earlier investigations from our laboratory revealed increased oxidative damage in SLE patients. Therefore, we hypothesized that oxidative by-products, such as hydroxyl radical (√OH), could lead to neoantigens like √OH damaged human serum albumin (HSA), which could in turn initiate autoimmunity in SLE (21).”

Woman statue resizedSo back to the recipe,

So now we have,

#1) hypersensitivity undiagnosed

#2) chronic inflammation causing degradation of mesh

#3) chronic infections from mesh porosity size allowing bacteria a safe haven

#4) chemical insults, the degradation products of the oxidative process caused by FBR which are free radicals, the most worrisome being hydroxyl

 

#5 Oxidative Stress and Damage

The recipe for a systemic storm is not complete yet.

Consider a statement by Kurien BT, Hensley K, Bachmann M, Scofield RH. 2006 May 23.

“Free radical-mediated oxidative damage and consequent protein modification by the end products of oxidative damage are important mediators of cell toxicity and disease pathogenesis”.

(Free Radic Biol Med. 2006 Aug 15;41(4):549-56. Epub 2006 May 23. Oxidatively modified autoantigens in autoimmune diseases.)

http://www.ncbi.nlm.nih.gov/pubmed/16863987?dopt=Abstract&holding=f1000,f1000m,isrctn)

We can now add oxidative damage or stress to the growing list of recipe ingredients for a damaging systemic storm. According to many research articles oxidative stress is implicated in autoimmunity onset, progression and exacerbation.  (8, 9, 10,11   ).

For example, in the paper by MR Namazi, (http://www.jautoimdis.com/content/6/1/4 Cytochrome-P450 enzymes and autoimmunity: expansion of the relationship and introduction of free radicals as the link …..) we can read about the link between chronic oxidative stress and the evolution or trigger of autoimmune disease.

“ Hydroxyl radicals are also very highly reactive and could attack a wide range of targets. The presence of rheumatoid factors in some autoimmune diseases, such as vitiligo [9,11] and rheumatoid arthritis, can be explained by this mechanism. Over time, chronic oxidative stress could generate several adducted and/or non-adducted molecules that would essentially act as a “neo-antigens”. This is consistent with the slow maturation of auto-antibodies in the evolution of autoimmune diseases. During chronic oxidative stress, neo-antigens potentially cause tissue damage and release a plethora of sequestered auto-antigens. This process is referred to as the “bystander effect”. Such an outburst of auto-antigens from the target tissue would potentially amplify the effect of the neo-antigens, leading to the breakdown of self-tolerance [8].”

Furthermore , according to Dr. Ray D. Strand, MD,

“There has been great interest among researchers for the past 20 years involving the role of oxidative stress in the development of arthritis. Most studies have not separated rheumatoid arthritis and osteoarthritis (degenerative arthritis) when looking at free radical reactions and these diseases. Information provided here is consistent with a comprehensive review article written by Dr. Henrotin in 1992 regarding oxidative stress and how it is involved in inflammatory joint disease. Several recent studies have further established oxidative stress as being the plausible cause of these diseases.”

“The immune system is intended to be our reliable protector. It is always checking for self (one’s own body) while it is looking for non-self (any foreign substance or abnormal cell). When the immune system finds a virus, bacteria, or foreign body it destroys and eliminates it from the body. However, in autoimmune diseases the immune system actually attacks itself rather than a foreign substance. If it attacks the joint space, a person is diagnosed as having rheumatoid arthritis. If it attacks the bowels, it manifests as Crohn’s disease or ulcerative colitis. When the connective tissue is attacked, a person might end up with scleraderma or lupus. If the myelin sheath around the nerve is the target, multiple sclerosis (MS) ensues. (www.raystrand.com/recommendations )”

Transobturator surgery

Transobturator surgery

Note the statement that recent studies established oxidative stress as being the plausible cause of autoimmune diseases. Now who in their right mind would argue that mesh complication patients don’t have oxidative stress when enduring chronic painful FBR? So I will add oxidative stress to the recipe.

So now we have,

#1) hypersensitivity undiagnosed

#2) chronic inflammation causing degradation of mesh

#3) chronic infections from mesh porosity size allowing bacteria a safe haven

#4) chemical insults,degradation products of the oxidative process caused by FBR which are free radicals, the most worrisome being hydroxyl

#5) oxidative stress

When you look at that recipe and realize that chronic FBR goes undetected for long periods of time (sometimes years) in mesh complication patients, you may wonder why is it going undetected for so long?  It appears that doctors are not looking for FBR symptoms!  They don’t see what they do not recognize!  Chronic FBR causes mesh degradation, causes systemic chain reactions, and causes autoimmune vulnerability. When delays in diagnosing mesh complications initiated by FBR happen, when misdiagnosing mesh complications as irritable bladder happen, it is like planting an autoimmune disease seed in a hot bed and  then wondering why it grew so quickly and strong!  The recipe ingredients outlined are all in mesh complication patients! Why are so many doctors seemingly oblivious to the obvious? My answer would be liability and accountability.  The links are all there if one chooses to seek them…, one reaction sets off a chain reaction. So no surprise is among mesh victims sharing info about autoimmune issues after FBR to synthetic mesh. There is sadness, anger, and grief as many mesh complication victims not only learn to live with chronic pain but irreversible autoimmune diseases as well.

I believe future studies will prove that autoimmune diseases, are being diagnosed at higher rates in the population of women who have experienced extreme chronic FBR to synthetic mesh than those of the population with no synthetic implants or no known FBR to implants that have not degraded or caused adverse events. I believe this statement would hold true for our male counterparts with hernia mesh complications. Research needs to be focused on the systemic effects of FBR induced mesh complications.

Doctors, especially primary care givers need to be educated to know the signs of FBR in their mesh implanted patients, and understand the progression from FBR to implant failure to autoimmune disease. Mesh complications are complicated!

It is not just about pain, erosion, extrusion, infection, organ perforation, the inability to sit, to have sexual relationships. It really is about quality of life issues that are not reversible, that are a whole body injury from a less than perfect implant material. Systemic effects from mesh can kill slowly or quickly.

Make no mistake, mesh can kill. Call it slow death by mesh if no doctor can remove your mesh implant or is willing to try when you are one of the not so rare patients experiencing chronic FBR, and in the eye of the perfect storm for a disaster.   Am I being dramatic? Some doctors might think so. Patients with mesh complications would say no, no drama; it just is the way it is.

My survey of a group of patients with medical mesh complications results show that post implant surgery;

12% developed diabetes, or been diagnosed as pre-diabetic.

51% experienced Weight loss

3% developed asthma

20% reported exacerbation of pre-existing asthma

3% diagnosed with Lupus

12% developed rheumatoid arthritis

10% reported exacerbation of pre-existing arthritis

100% noticed a marked lack of energy post implantation, chronic fatigue

14% diagnosed with chronic fatigue syndrome

71 % have undiagnosed chronic fatigue symptoms

24% diagnosed with fibromyalgia

41% reported  symptoms of fibromyalgia to be addressed or being addressed

63% reported blurred vision post mesh implant

44% reported having  elevated fever, higher body temperature

39% reported  lower body temperature

44% reported  Hair loss, loss of facial and scalp hair

17% reported Hyperpigmentation, or dark tanning in skin

29% reported  Painful skin rash,

25%    reported Fragile thin skin

36%  reported Skin that bruises easily

24%    reported acne

24%    reported Skin rashes, especially “butterfly rash” on the nose and cheeks

41%   reported Sun sensitivity

46%  reported dry eyes

44%    reported   dry mouth

51% reported  extreme sensitivity to cold in the hands and feet

76%   reported   Recurring abdominal bloating and pain

39%    High blood pressure

90%   Irritability, anxiety and depression

92%  reported  “Brain Fog,” difficulty concentrating,

53%     reported  Lack of coordination or unsteady gait

61%   reported Dizziness, vertigo

58%  reported Numbness, weakness, tingling or paralysis in one or more limbs

27%  Tremors

25%  Cysts on Ovaries

41%  Increase in snoring

63%  Shortness of breath and tightness in the chest

22%  Unexplained anemia (low count of red blood cells

8%  diagnosed with a connective tissue disorder post mesh

2%  have you been diagnosed with cancer post mesh implantation

32%  reported  chemical sensitivities started post mesh implantation

41 % reported food sensitivities started post mesh

What could these symptoms indicate ?

What are these symptoms associated with? You guessed it ….autoimmune diseases!    Clearly we need research and scrutiny into the progression from foreign body response from synthetic mesh to autoimmune diseases development.  Clearly if one researches one can see the dots connect! I suspect those who have the most to lose will not look, research or admit to causing autoimmune problems by using non-inert mesh in highly susceptible patients. And here is a big question … if mesh becomes non-inert in 33% of the people it is implanted into, is the mesh defective?

Clearly, mesh degrades. Is that not a defect? It is designed to be permanently implanted so one would not find it a stable product if 33% of the meshes implanted degrade and the implants fail. This is a Pandora’s box. Who is brave enough to take on the manufacturers ? Is the ultimate liability so scary the judicial system will avoid finding the product defective but give higher punitive awards for failure to warn?

Well, that question is food for more thought, to add to what I have already tried to piece together for a clearer picture of why implant rejection and failure is more than just a localized wound, but the starting point for a host of autoimmune systemic problems going unrecognized, unresearched, and untreated.

Mesh strands from Wideman urine

Mesh strands from Wideman urine

 

LEARN MORE:

 References

1)    http://www.pqri.org/workshops/leach_ext/imagespdfs/posters/Polymer_Additives_PQRI_Poster.pdf

2) Long-term foreign-body  reaction to preperitoneal polypropylene mesh in                       the pig,      G. L. Beets, H. van Mameren, P. M. N. Y. H. Go

http://link.springer.com/article/10.1007/BF01569134

3)http://www.envita.com/cancer/chronic-inflammation-fuels-development-of-stage-cancer/

4) Oxidative Medicine and Cellular Longevity Volume 2011 (2011), Article ID 809696, 9 pages doi:10.1155/2011/809696 Review Article Hydroxyl Radical and Its Scavengers in Health and Disease,Boguslaw Lipinski, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA Received 30 March 2011; Accepted 7 June 2011 Academic Editor: Kennet Maiese  http://www.hindawi.com/journals/oximed/2011/809696/

5) Systemic effects of biomaterials Biomaterials ,Volume 5, Issue 1, January 1984,Pages http://www.sciencedirect.com/science/article/pii/0142961284900619

Jonathan Blac

University of Pennsylvania, Philadelphia, Pennsylvania, USA

http://dx.doi.org/10.1016/0142-9612(84)90061-9, How to Cite or Link Using

Abstract: Evaluation of the host response to implanted biomaterials usually focuses on the implant site tissue response. This may lead to erroneous conclusions in the same way that examination of battles outside of their historic context does. A broader view discloses a variety of possible and actual systemic effects of carcinogenic, metabolic, immunological and bacteriological nature. Recognition of these effects in patients is hampered by a lack of epidemiological studies.

Keywords

6) Autoimmunity. 2007 Nov;40(7):512-20.

Enhanced recognition of reactive oxygen species damaged human serum albumin by circulating systemic lupus erythematosus autoantibodies.

Sheikh Z, Ahmad R, Sheikh N, Ali R.,Source Department of Biochemistry, Faculty of Medicine, AMU, Aligarh, India. zrasheed@rediffmail.com  http://www.ncbi.nlm.nih.gov/pubmed/17966041

7) The mechanisms of oxidative degradation of biomedical polymers by free radicals

http://onlinelibrary.wiley.com/doi/10.1002/app.1994.070510805/abstract

S. A. M. Ali, P. J. Doherty, D. F. Williams*

Article first published online: 10 MAR 2003

DOI: 10.1002/app.1994.070510805

Abstract

Degradation is an essential factor in polymer biocompatibility. The physiological environment of the human body can be aggressive to polymers. Most implanted polymers suffer degradation and the kinetics and mechanisms of the processes can be significantly affected by various biologically active species, especially enzymes, lipids, peroxides, free radicals, and phagocytic cells. Iron enhances the toxicity of oxygen free radicals. Superoxide and hydrogen peroxide can interact to form the very toxic hydroxyl radical in the presence of iron. The data have shown that the hydroxyl radical is likely to be one of the main causes of polymer degradation in implantable devices. © 1994 John Wiley & Sons, Inc.

8) http://europepmc.org/abstract/MED/12799017

“Increasing evidence shows that oxidative stress plays an important role in the pathogenesis of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE).”

9) http://www.ncbi.nlm.nih.gov/pubmed/22291449

Oxidative stress promotes hypertension and albuminuria during the autoimmune disease systemic lupus erythematosus.

10) Source http://www.ncbi.nlm.nih.gov/pubmed/22291449

Mathis KW, Venegas-Pont M, Masterson CW, Stewart NJ, Wasson KL, Ryan MJ.Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216-4505, USA.

Abstract: Several lines of evidence suggest that essential hypertension originates from an autoimmune-mediated mechanism. One consequence of chronic immune activation is the generation of oxygen-derived free radicals, resulting in oxidative stress.

11) http://www.ncbi.nlm.nih.gov/pubmed/16863987?dopt=Abstract&holding=f1000,f1000m,isrctn

Kurien BT, Hensley K, Bachmann M, Scofield RH.

Source :Free Radic Biol Med. 2006 Aug 15;41(4):549-56. Epub 2006 May 23.

Oxidatively modified autoantigens in autoimmune diseases. Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, OK 73104, USA.

AbstractFree radical-mediated oxidative damage and consequent protein modification by the end products of oxidative damage are important mediators of cell toxicity and disease pathogenesis. Aldehydic products, mainly the 4-hydroxy-2-alkenals, form adducts with proteins and make them highly immunogenic. Oxidative modification of proteins has been shown to elicit antibodies in a variety of diseases including systemic lupus erythematosus (SLE), alcoholic liver disease, diabetes mellitus (DM), and rheumatoid arthritis (RA). Oxidatively modified DNA (8-oxodeoxyguanine) and low-density lipoproteins (LDL) occur in SLE, a disease in which premature atherosclerosis is a serious problem

12)http://journals.lww.com/greenjournal/Abstract/2010/10000/Polypropylene_Vaginal_Mesh_Grafts_in_Gynecology.24.aspx  Polypropylene Vaginal Mesh Grafts in Gynecology,Ostergard, Donald R. MD,Obstetrics & Gynecology:

October 2010 – Volume 116 – Issue 4 – pp 962-966

“ Noninert polypropylene degrades into potentially toxic compounds that would be expected to stimulate a greater inflammatory reaction leading to erosion……….Manufacturers need encouragement to develop meshes that are inert and incorporate without contraction along with routine clinical tests to detect “high responders” to avoid complications. Polypropylene is not inert within the human body.”

13) http://www.lifebeatonline.com/procedure/ProcedureLanding.bsci/,,/navRelId/1000.1002/method/Procedure/id/10001031/attributeTypeId/1/resourceTypeId/91/seo.serve     CONTRAINDICATIONS….Autoimmune connective tissue disease……

14) http://www.ehcd.com/Implant_Syndrome_070711.pdf

IMPLANT SYNDROME ,William J. Rea, M.D., F.A.C.S., F.A.A.E.M.

“The surgical use of artificial implants can induce both autoimmune disease and chemical sensitivity.”

15) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708803/)

16) http://link.springer.com/article/10.1007%2Fs00192-012-1678-2?LI=true

A standardized description of graft-containing meshes and recommended steps before the introduction of medical devices for prolapse surgery

Mark Slack, Donald Ostergard, Mauro Cervigni, Jan Deprest,International Urogynecology Journal,April 2012, Volume 23, Issue 1 Supplement, pp 15-26

Abstract: Over the past decade, a huge number of new implants and ancillary devices have been introduced to the market. Most of these have become clinically available with little or no clinical data or research. This is a less-than-ideal situation, and this subgroup of the ad hoc IUGA roundtable conference wants to open the discussion to change this, by proposing a pragmatic minimum clearance track for new products being introduced to the market. It consists of an accurate and more standardized product description, data on the biological properties gathered in animal experiments, anatomical cadaveric studies, and upfront clinical studies followed by a compulsory registry on the first 1,000 patients implanted. Ideally, manufacturers should support well-designed prospective (randomized) clinical trials that can support the claimed benefits of the new product. Data were presented at the 2nd IUGA Grafts Roundtable June 2010.

17) http://clinicaltrials.gov/ct2/show/NCT01428167?term=chronic+inflammation&rank=85      Hashimotos Thyroiditis and Thyroid Cancer

Sponsor:The University of Texas, Galveston Information provided by (Responsible Party):The University of Texas, Galveston ,ClinicalTrials.gov Identifier:NCT01428167,First received: August 10, 2011 Last updated: June 5,

Thyroid cancer (TC) is the most common endocrine malignancy. The association between inflammation and cancer is well established.

18) http://www.envita.com/cancer/chronic-inflammation-fuels-development-of-stage-cancer/

Inflammation can become chronic if the cause of the inflammation persists, or because of deregulation in the control mechanisms responsible for shutting down the inflammation process. When these inflammatory responses become chronic, cell mutation and proliferation can result and often create an environment that is conducive to the development of cancer.

Inflammation is the body’s response to tissue damage, caused by physical injury, ischemic injury (caused by an insufficient supply of blood to an organ), infection, exposure to toxins, or other types of trauma. The body’s inflammatory response causes cellular changes and immune responses that result in repair of the damaged tissue and cellular proliferation at the site of the injured tissue. Inflammation can become chronic if the cause of the inflammation persists, or because of deregulation in the control mechanisms responsible for shutting down the inflammation process. When these inflammatory responses become chronic, cell mutation and proliferation can result and often create an environment that is conducive to the development of cancer. This is often referred to as “the perfect storm.”

19) http://www.sciencedirect.com/science/article/pii/0142961284900619

Jonathan Blac, Systemic effects of biomaterials, Biomaterials Volume 5, Issue 1, January 1984, Pages 11–18Biointeractions ’84 Materials/Interactions-Conference Systemic effects of biomaterialsUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA

20) http://onlinelibrary.wiley.com/doi/10.1002/app.1994.070510805/abstract

The mechanisms of oxidative degradation of biomedical polymers by free radicals ,S. A. M. Ali, P. J. Doherty, D. F. Williams*,Article first published online: 10 MAR 2003 ,DOI: 10.1002/app.1994.070510805

21) http://informahealthcare.com/doi/abs/10.1080/08916930701574331

2007, Vol. 40, No. 7 , Pages 512-520 (doi:10.1080/08916930701574331)

HTML PDF (213 KB) PDF Plus (217 KB) Department of Biochemistry, Faculty of Medicine, AMU, Aligarh, 202002, IndiaDepartment of Biochemistry, SBSPGI, Balawala, Dehradun, 248161, IndiaDivision of Pharmacology, Central Drug Research Institute, P.B. No. 173, Lucknow, Indi

22) (http://www.immed.org/illness/autoimmune_illness_research.html

23) http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2249.2003.02104.x/full

H Ahsan, A Ali, R Ali – Clinical & Experimental Immunology, 2003 – Wiley Online

Summary: Reactive oxygen species generated during various metabolic and biochemical reactions have multifarious effects that include oxidative damage to DNA leading to various human degenerative and autoimmune diseases.  #

 

 

 

 

 

 

 

57 Comments

  1. I have been diagnosed with a rare infection Acidovorans after mesh removal February 2013.

    I ask once again has anyone else ever heard of this infection

    • Kathleen says:

      Teresa this Acidovorans has been found round oil, and from what I have gathered degrades the oil. Our scientists in turn have a wonderful way of making more of these natural bacteria so that they can degrade even more oil, as in spills of oil. Our Polypropylene mesh devices are made from oil, so was this bacteria trying to get rid of your mesh, but in turn causing you to be ill. I would in fact say that this bacteria comes about as part of the degrading of oil or plastic. Oil and plastic are not designed to go inside our bodies and if they were we would be able to eat and drink them.

    • Bejah Blue says:

      So sorry Teresa, and I have not heard of this but will keep my eyes open and let you know. You may need to do some deep research yourself at serious academic and research sites, maybe contact some top physicians in this area of medicine, infectious diseases (?), etc. Prayers with you.

  2. George says:

    Thank you so much Nonie and Jane,

    I checked off 14 of those symptoms and am currently being tested for MS, fibromyalgia, ALS, tumors, cancer, and demyelination diseases. All of which have a basis in the immune system. These also share the problem of lacking a strict test for a complete diagnosis. We need a study where 1000s of mesh complication victims provide blood which is analyzed for common components that are elevated or diminished. My guess is there will be several blood traits we all have in common related to FBR.

    I have learned to never underestimate the problems and pain we have or can have. Since my mesh complications has gone “systemic” with very sharp nervous system pain, those days of chronic belly pain from eight surgeries in six years (4 adhesion lysis , 2 mesh in, 2 mesh out ) does not seem so bad. Thankfully anti-seizure medications keep me going now.

    Thank you again for this literature review and I hope all MDND readers will disperse it far and wide to their medicos.

    G

    • Bejah Blue says:

      Good ideas but how to make it happen, who is going to fund it. I am A+ BTW and have demyelinating issue diagnosed pre op, and peripheral neuropathy diagnosed post op., so many things…hard to remember them all, Vulvodynia and Intersistial Cystitis diagnosed post implant, etc.

      One thing we must remember is that some things we have mentioned here are typical for aging women like Diverculitis, some degree of constipation, dry mouth, difficulty urinating but that does not mean they are not also existent features of mesh implantation and exaggerated because of that. If your urine is strong smelling drink more water…that is psychologically troubling, I know. Use aroma therapy to combat it as you can in your home. I have downloaded all of this post and comments and have not read it all yet, “a keeper” it is! Nice to hear from some of you that we have not heard from for awhile! 🙂

  3. Diane Fichter says:

    Simply brilliant as usual!!! You have given the medial profession a lot of food for thought! I hope they take heed that we will no longer be silenced! Mesh has robbed me personally of so much I cant even begin to describe it…I now have SLE Lupus, a co-incidence, I think not…I have also had to make some horrible sacrifices when my Mom just recently had 2 heart attacks…I couldn’t go see her as a hospital environment for a Lupus patient is deadly…

    Nonie, I thank you from the bottom of my heart for your relentless research….you have put your heart and soul into your research and you deserve to be acknowledged! Like I’ve always said to you, your hard work and efforts do not go unrecognized, we love and appreciate what you do for us…

    Your our shining star in an often gloomy dark sky…Thank you for never giving up…with love always….

  4. I would be thankful if you could all sign our petition for the women in England.

    I put the incorrect link on before.

    http://www.gopetition.com/petitions/the-medicine-health-regulator-united-kingdom-are-failin.html

  5. Have you ever heard of Costochondiritis which is inflammation of the chest/ribs which is what Fibromyalgia sufferers are prone to.

    I have had this since last October and it is very painful. People think that they could be having a heart attack with breathing difficulties and stabbing pains in the chest.

    I hope this may help sufferers of mesh.

  6. Dear Nonie,

    A great article and thank you for your amazing efforts to increase the awareness of ongoing mesh complications. Knowledge is power!!

    Patricia NZ

  7. Thank-you so much for this wonderful research and information concerning mesh implants and autoimmune diseases! I had a mesh bladder sling implanted 10 years ago, and I have had bizarre, multiple health problems for, at least, 7 years or more, starting with chronic fatigue, hemolytic anemia, severe infections everywhere, skin eruptions,rashes, allergies to many drugs, etc.,…and now…dry eye problems, dry mouth, and alarmingly advanced periodontal disease and tooth loss! I began researching autoimmune disorders and found Sjogren’s Syndrome, which fits my health profile. I saw a Urologist this week who said that my bladder pain and urethritis were definitely due to the mesh. (He could actually FEEL the mesh through a vaginal exam!) He offered to ” go in and cut the sling apart to clear my urethra!” No way! That mess has to go or I will be dead soon…I’m serious!

    My question is this: where do I find a doctor who is able to remove ALL of the mesh, and, at least, is willing to BELIEVE that polypropylene mesh degrades via oxidative processes and becomes TOXIC to the body? I want to have the surgery done laparoscopically if possible. I live in Georgia ( near the GA/FLA border), but am willing to travel. Somebody please answer if you can help me… Thanks so much.

    • Perry says:

      Valerie,

      I am from south Ga- close to Fla border, and had mesh sling operation for urinary stress incontinence in 2003. I have had so many problems and did not even realize that several of the issues were caused from the mesh until recently. I too have had advanced periodontal disease,prime example- is this a result of vaginal mesh? I have had debilitating back pain for years among many, many other issues ; uterine prolapse, cystocele , rectocele, abdominal pain, pressure as if all of my organs were coming out of my bottom… Please, if you find a doctor, I need one desperately!!! I can hardly walk until I have had pain medication and then still have a hard time. This is no way to live!!!

      My vaginal mesh surgery was in 2003 and by 2005 my back was hurting me so badly that I ignored my other problems. I was diagnosed with scoliosis in 2005 and by 2008 I was bed ridden.I had rods and screws surgically placed in 2009- this was such an intensive surgery that I could not lift my arms for 6 months. I am saying this because I was wondering if there is a possible connection. It just seems odd that at age 34 I suddenly had severe scoliosis! Anyone have any similar problems?

      • Gay Courter says:

        I went to the dentist after my mesh removal for a regular check up and has 7 cavities! Have had excellent dental health and routine care. No problems in years and never multiple issues. Told dentist about the mesh and he did not discount it. Mesh sets up a constant irritating and infectious process in the body so it could have undermined many areas of health including dental. I think all women with mesh need regular dental check ups.

        • Betty says:

          Yes, I meant to comment on this. All meshies should see a dentist. Whether its grinding teeth at night due to pain or infection that cannot be controlled well due to a down immune system we only have one set of teeth (we’re not babies). My teeth are now very sensitive (I think due to grinding at night). I know some who’ve had cavities and root canals. Pain medications are another reason why we need to go – they mask any normal dental pain we might feel and then we end waiting too long to take care of a problem. The number of mesh complications are mind boggling. The fact that the companies knew of (most) the complications is so disturbing. How dare they treat us as statistics!

          • lesa says:

            For real I’m living a real life horror movie that I can’t escape as with many of you and so sad that we now face this horror without a good doc ,its all that I can do to keep the strength to stay alive and my children have also suffered.As a parent you are to be strong but since the mesh I’ve been anything but that my life is destroyed ,somebody anybody please HELP US please.its sad that we will never be well and have to live our lives out with more medical bills due to the stress and physical damage and pain its just not fair I miss my life,you are all in my prayers.

        • Bejah Blue says:

          Hi Gay, I discovered I have five cavities (rarely ever had one before), needed three root canals (Never had one before), need a deep cleaning and now because I did not have the money to save it in time, I need a bridge lower front. I have high option Delta ins but it does not cover a majority of these costs and I expect they will continue if I do not watch closely from now on. Very depressing. The sense of betrayal grows…almost unbearable.

      • Donna Harris says:

        Doctor Lorie G Fleck Mobile Alabama she was able to remove all my mesh still having complications no doubt autoimmune but I have lost my insurance and have run out of money to continue my quest for good health .Good luck to all women who suffer

        Donna Harris

        Pensacola Florida

      • Carol S. says:

        If you are near Pensacola there is a great mesh surgeon in Milton XX. His name is Dr. XXXXX. He is a Board Certified Pelvic Reconstructive Surgeon and has done a great job for me. i hope this helps you

        • Jane Akre says:

          Hi Carol- I’m sorry if Dr. X would like to advertise on this site I will be happy to discuss that possibility with him. We do not take ads in the comment section. If you are a genuine patient who liked this doctor and want to promote him, encourage him to contact me at janeakre@meshnewsdesk.com …. But you must understand, not all advertisement is taken. For example you cannot be putting in mesh and removing it as part of your protocol. That is the opinion of your editor. Thank you! ~ ja

  8. A meshed up nurse says:

    Dear Nonie, Thank you got writing this. You put so beautifully into words what I have been trying to articulate for years! This paper is brilliant and should serve as a wake-up call to all medical professionals, especially those who have been working under the idea of mesh being inert, mesh manufacturing companies, researchers, and patients.

    Pandora’s box is now open and there’s no putting her back. Open your eyes everyone and see what is right in front of you.

    The development and exacerbation of auto-immune syndromes and diseases from implanted synthetic mesh is a serious situation that warrants further investigation. The hundreds of thousands of mesh-injured patients worldwide deserve answers to their serious decline of overall health.

    The only thing that I might take exception with is the concept that some of these auto-immune issues might not be reversible. I do believe that if most or all of the mesh is removed (which is much easier said than done), as soon as possible when these problems are first noted to be starting, and before the activation of the body’s systemic response has progressed too far, then it is possible to diminish the body’s “over response” that the mesh started. The mesh needs to be removed and the patient needs to be on a concentrated program to restore his or her health by proper nutrition, supplements including probiotics, vigilence regarding past infections, yoga, mediation, exercise as able, stress reduction, and other activies to return physical and emotional balance back to the body.

    As Nonie says though, first the underlying cause of the symptoms and illness exacerbation must be identified and addressed, which is the synthetic mesh implant.

    Thank you, Nonie, for a very well written and research supported paper that should help to open the eyes of many.

  9. Jane Akre says:

    Lesa- Are you able to get some medical help? Please go to the Facebook page associated with this site and ask others who have been there for some direction in your area of the country, or if you have insurance, seek out the best medical professional you can. Thank you for writing, many have found relief when they advocate for themselves….

  10. Sharon Patterson says:

    Oh my gosh Nonnie you just answered questions that have been plaguing me and my Doctors. I have had four hernia surgeries with mesh implants over the last 10 years. After the first one I had two separate bowel blockages that had to be repaired. The other two surgeries that led up to all of this was gal-bladder and stomach ( Nissan Fundoplication) surgery. I remember the surgeons having me sign releases but never did they warn me of the reactions my body might have to the mesh implants they used.

    After my Stomach (1998) surgery I remember the incision sight became infected to the point that I became sick with a fever and flu-like symptoms. It swelled up to the size of a baseball. The surgeon had me come in and he drained it. After that I felt better. The point I’m trying to make is that my FBR was apparent then and I should have been warned but wasn’t.

    Now my blood tests show that I have inflammation in my body but my rheumetologist can’t figure out what I have. I just had a skin biopsy for psoriasis (psoriatic arthritis) that came back negative, and that my rash indicated an internal cause. After reading your article I believe that it is from the mesh implant or internal sutures because I have had this rash which is surrounding the incision site since the last hernia surgery (2011). The doctors now are trying to pinpoint the reason for the inflammation. They, nor I, have even mentioned anything to do with the mesh implants. It all makes sense because of the Foreign Body Response that you speak of. I have been living with symptoms of several auto-immune diseases but no doctor will say which one. I am going to present your theory to my doctors and see how they respond. I have taken several different medications for arthritis but the side-effects have been overwhelming. I have many questions about removing the mesh implants but it sounds like people have had many negative outcomes from doing so. About a year after my last hernia surgery another one popped out. So I must be destined to having this problem. I just know that I won’t have this one repaired with a mesh.

  11. Sharon Patterson says:

    Oh my gosh Nonnie you just answered questions that have been plaguing me and my Doctors. I have had four hernia surgeries with mesh implants over the last 10 years. After the first one I had two separate bowel blockages that had to be repaired. The other two surgeries that led up to all of this was gal-bladder and stomach ( Nissan Fundoplication) surgery. I remember the surgeons having me sign releases but never did they warn me of the reactions my body might have to the mesh implants they used.

    After my Stomach (1998) surgery I remember the incision sight became infected to the point that I became sick with a fever and flu-like symptoms. It swelled up to the size of a baseball. The surgeon had me come in and he drained it. After that I felt better. The point I’m trying to make is that my FBR was apparent then and I should have been warned but wasn’t.

    Now my blood tests show that I have inflammation in my body but my rheumetologist can’t figure out what I have. I just had a skin biopsy for psoriasis (psoriatic arthritis) that came back negative, and that my rash indicated an internal cause. After reading your article I believe that it is from the mesh implant or internal sutures because I have had this rash which is surrounding the incision site since the last hernia surgery (2011). The doctors now are trying to pinpoint the reason for the inflammation. They, nor I, have even mentioned anything to do with the mesh implants. It all makes sense because of the Foreign Body Response that you speak of. I have been living with symptoms of several auto-immune diseases but no doctor will say which one. I am going to present your theory to my doctors and see how they respond. I have taken several different medications for arthritis but the side-effects have been overwhelming. I have many questions about removing the mesh implants but it sounds like people have had many negative outcomes from doing so. About a year after my last hernia surgery another one popped out. So I must be destined to having this problem. I just know that I won’t have this one repaired with a mesh.

  12. Thank you so very much on your amazing research and findings. I admin a FB group called Essure Problems. Essure is a medical device implanted into a woman’s Fallopian tubes to render her sterile. The “new and improved tubal ligation”. The metal coils have PET fibers wound throughout them. The PET fiber is the same as found in mesh implants. We are experiencing the SAME EXACT symptoms and diagnosis. I will be following all of your articles regarding this issue and tweeting my little heart out to share your much needed information. You are a God send. And you bring to light and provide the evidence we all needed to connect the dots we knew were there.

  13. Maria says:

    Thank you for this research, I to had Essure and my entire body gradually became inflamed, the pain was debilitating for years. My issues began within months of being implanted. But what concerns me is that my daughter who is now 23 had a hernia fixed when she was 4, two years ago she was diagnosed with SLE. The thought that our governement had some idea of the dangers synthetic pose to the human body angers me. We trust or Drs to do what is best for us, who do we trust…

  14. Kirsten Kirch says:

    Thank you for posting this. I had the medical devices known as Essure implanted, and I have had nothing but problems for the last 2 years. This helps me to understand what’s going on inside my body between FBR, the mesh and the nickel coils. It explains so much, thank you.

  15. Stephanie Nagy says:

    Thank you very much for this interesting article. I had the Essure device implanted for 4 years. It also has polypropylene. I developed chemical sensitivities, food sensitivities, and experienced weight loss. I am not able to touch most things that are made from chemicals (soap, lotion, makeup, hand sanitizer, hair dye, nail polish, household cleaners). I have had anaphylactic reactions from casual contact with things like soap. During the worst reaction I was hospitalized a number of times in a two week period and the right half of my body went numb. I was so ill that I couldn’t drive for over 5 weeks. I became anaphylactic to so many foods that my weight was down to 92 pounds. I saw many doctors at top research facilities who could not diagnose the cause of my severe allergic reactions to chemicals and foods.

    I didn’t start to have pain at the site of the implants until the last year that I had the implants. When I started having pain, I started looking into the possibility of Essure causing my other problems. I was amazed to find out I was not the only person to develop extreme allergic responses after having Essure implanted. I am eternally grateful to the doctor who said she would remove my implants. I had Essure removed via a complete hysterectomy (everything was taken except my ovaries) 8 months ago and am feeling better each day. I still have severe allergic reactions-but they are less severe and I don’t take as long to recover. I have gained almost 10 pounds. I am now sensitive to nickel and silver which were also in Essure. I am hopeful that after I have my fillings and crowns replaced with something non metal that I will begin to heal even more. Essure has turned my life completely upside down. I was a mildly allergic person before Essure and never had an anaphylactic reaction.

    I very am thankful to you for this article. It looks like I have some research to do about the effects of polypropylene inside the body. I hope to be able to pass this along to my doctors too.

  16. Thank you for posting this valuable information. The symptoms are also experienced by Essure victims. Doctors still will not listen and remove the coils. The fibers in the coils are PET same compound of mesh. Awareness is needed or these products will continue to be made and people will continue to suffer. For those that might have mesh and Essure, please look at the Essure website for other information.

  17. Terri says:

    I am in tears. 23! TWENTY-THREE ! And, I’m being more than easy on the #on that list. I’m 48. I’ve been diagnosed with and treated for scleroderma, then lupus, now fibromyalgia class IV.

    Latest thing going with a Dr. that seems to give a flip ( I’m trying to temper my words as much as possible) Connective Tissue Disorder…. I hope you all can imagine a tough , TRULY independent woman …raised in a good ol’ southern state-working my way thru life the dumb way, with my common sense and muscles…. Even after husband killed in wreck leaving 3 little kids…not one dime of help. Then 18 years of busting my “rear” for the P.O. ,a partial hysterectomy, a year later a bladder hammock, then hit the wave…..fusion of cervical spine 2 levels,5 hand surgeries, cysts in bone and muscles, torn cartilage in 4 joints, now, I’m looking at surgeries being lined up for a shoulder, both knees, both feet and both hands again. I was fired from the USPS for being unable to work and none of the individual specialists filling out paperwork because the exact thing they looked at wasn’t enough to keep me from working. I I feel like a slug, that someone has hit with a sledge hammer then poured salt on about 90 % of the time. Thank the Lawd that I remarried just in time for all this crap to hit the oncoming tornado of downward diving health ! He is a saint, and why he hasn’t run screaming head first into oncoming traffic, I couldn’t tell you, cause I sure want to-EVERY STINKING DAY ..The insensitivity/specialist@ UAB ACTUALLY said to me-” I hate having patients like you, you used to be highly functioning. Now, you think you are handicapped because you don’t feel good and you hurt” I was on medication, and why I didn’t jump up and choke her eyeballs out while I had a case that would hold up in court,…????? Being that I began peeing blood for the last 20 hours, I’m almost sure I’m ready to load up and go find someone to get this sh 😛 t out of my body, all of it, and give me my life back, just like it was plus the lost years, or face a handicap of their own-my choice of course. What I want to know is, after it is in there, done some damage that shows up, can you get it out and reverse even some of the effects? I’d make them a settlement offer, I’ll give up on the lost 5 years-with my husband, kids, and grands losing out on having the real me all this time-just let me have what I’ve got left without all this added crap (provided I get to mash various body parts of the members of the FDA that passed these devises in the first place under the tires of my hummer any ol’ time I choose for, oh, how many years has it taken them to START the wake the hell up process? I’m mad, not at anyone here, but just the same mad. I’m sure I will be dust before the grand Poo Pas in control of what is decent and right without big ol’ words and deep pocketed attorneys taking the majority of dirty money to admit a dang thing- then once all of us who have endured their stupidity and pain beyond their scope are gone, they can giggle all the way to an extra hot place in hell, one they have earned. One day soon, I suspect I’ll be given a expiration date/death penalty because of this Dr/God thing that made me allow them to tell me ” no problem, easy peasy” & some way I sat there grinning saying “okeydokey, if you say so”…..words of wisdom to those idiots that made, approved, and installed these pieces of trash-watch out-there’s 5’3” bundle of doped up, red-neck coming your way, and she has no filters or fear left. Any woman out there, you’d be better off sewing your thighs together….at least from this torture chamber that is my own body, that’s my opinion

    • Jane Akre says:

      Terri-

      Are you in touch with medical help? I’m hoping there are some solutions for you that will put you in a better place. Please write back with your location and whether or not you have insurance..some patient advocates may help you create a plan …thank you~ ja janeakre@meshnewsdesk.com

  18. Christy Climer says:

    Omgosh Omgosh Omgosh Omgosh!!!! Please know how sincere I am. I had the bladder sling implanted in October 2009. This has to be the cause of my problems!!! I have suffered so severly. You have no idea. Not until recently did i connect by bizarre medical problems to this!!! I dont even know where to begin. Besides the severe pain and failing marriage because of my inability to have sex because of the pain, i also have skin problems to you wouldn’t believe. I have rashes and sores all over my body that will not heal. It seems as though I have a severe infection coming from somewhere in my body. I’m not able to go in public any longer because if I’m so ashamed of my doin sores. My neurological problems are horrible. Every bit of this started after my sling was implanted in. I could go on and on here. Ive lost my whole life since then. Every time Ive begged my doctor to listen to me that something is terribly wrong he ignores me. I want this thing out of me. I cant find a doctor to remove it. Can anyone please know help me??

    • Jane Akre says:

      Christy- First, you will need your medical records. Do you have insurance? Where are you located. Patient advocates can help direct you. Please let me know…. janeakre@meshnewsdesk.com

      • Prof.Edmond says:

        Just go back to the same surgeon and ask him to remove the mesh and see what is his reaction and check after with insurance if u covered, don’t say much

    • Dawn says:

      Hi Christy….I have not been to this site in awhile….Read your post and wanted you to know I can relate to the skin and neurologic issues…Had my Boston Scientific Lynx sling removed in July 2014…Curious as to how you are doing since your March post…Look forward to hearing from you…

      Dawn

  19. christina sheppard says:

    I found this fascinating as I have had a medical implant with some similar ingredients. In 2010 I had the Essure procedure done (a permanent birth control method in which tiny coils are placed in the fallopian tubes.) As a result of the Essure coils (which contain some nickel, PET fibers and several other polymers) I seem to be having a FBR. I am having an ocular manifestation, in that due to chronic inflammation, my retinal area developed scarring and blood seepage which has led to substantially decreased vision. In the last 18 months, when symptoms first developed, my vision went from 20/20 to 20/400 and continues to get worse. I am currently working on enlightening my Drs. that this is the cause, and will be having the coils removed (which means a hysterectomy) as soon as possible.

  20. Renee says:

    I had a mesh implated 10 years ago, and have chronic infections. I’m writing this to maybe help the ladies who get chronic infections. I have self treated my infections and other issues I have because of the mesh for the last 5 years. I started with D-mannose works pretty good. But I’d get a real bad infection and would have to take antibiotics maybe once or twice a year. Then I came across a book called MRSA secrets Revealed by Michelle Moore. I don’t have MRSA but anyone who takes alot on antibiotics are at a greater risk of getting MRSA. The book will teach you how to fight a infection naturally. I haven’t been on antibiotics since I got the book. I still get infections, but I now know what to take to prevent going to the doctors. For thining hair and skin I take Great Lakes Gelatin 2 x aday. I have been very sensitive to chemicals the last 7 years, so I don’t clean with them. I use natural stuff and make my own soap because of skin rashes. I also detox every six month with Total Tea Detox. It sucks this life style is very costly and time comsuming. I’m not 100% better but these changes have helped. The doctors meds made everything worse, probly because the meds are all chemicals. I have gotten my blood persure, liver count, and HDL all back to normal numbers. You really have to be proactive with your health. Renee

  21. Karen A. says:

    I started with auto immune problems about a year from my surgery and all the doctors said there is no explanation for auto-immune diseases. I knew there had to be a cause, this finally answers my question. I have some pain relief from methotrexate ( a horrible drug) but it stops the pain. I would like a more safer, permanent solution. Thank you for getting the word out. I’m going to study up on all of this and evaluate my next steps.

  22. Lewis Lafontaine says:

    About a year and a half ago I had a ventral hernia mesh implant operation.

    Increasingly over that past several month I have abdominal discomfort and pain that seems to be increasing in intensity.

    There is a constant in and around my lower abdomen.

    Constipation has been ruled out by taking 4 magnesium tablets and a dose of miralax daily.

    Also twice a week I have Senna tea.

    I do not know what is causing my pain and discomfort and am considering various hypotheses one of which is that it may be related to the Ventral Hernia Mesh implant but I am seeking informed guidance on the possibility that this might be the cause.

    I am wondering if there is a specific diagnostic test that could either rule in or rule out the hernia mesh implant as either the cause or a mitigating factor of my current abdominal distress.

    Thank you

    • Jane Akre says:

      Best hernia docs are Dr. Kevin Petersen in Las Vegas and the SHouldice Hospital in Toronto. Otherwise you may find a lot of delay and deny. Call Bruce Rosenberg at 954-701-5094, he is hernia mesh injured and very knowledgeable.

      • Sherri says:

        Dr. Peterson removed my hernia mesh in July 2014. Prolene mesh was used to during open surgery for my right inguinal hernia in August 2013. I still suffer from chronic pain but I can’t imagine where I would be today if I still had that horrible stuff inside me. I was in severe pain 24/7 and already experiencing alot of autoimmune symptoms. I still live with chronic pain, but I know my health would have continued to decline rapidly if I did not have that mesh removed. It did not reverse all of the damage, but it did stop the rapid deterioration of my entire body. Now I have hope of some slow improvements. I truly wonder if I would be alive today if I had not had the mesh removed when I did.

  23. Margie says:

    My sister had the bladder mesh surgery 10 years ago, she just passed away in June from a rare form of stomach cancer,Signet ring cell carcinoma. Could the bladder mesh have caused her cancer? No family history of any cancers until her. Please, if anyone knows, let me know.

    Margie

    • Jane Akre says:

      some studies on rats had shown cancer at the mesh implantation site. I remember reading that years ago.

    • Jenny says:

      Hi Margie – its Jenny. I found your post after looking into this myself. I was searching for these exact term words and this came up. I realized it was you. I’m still inquiring about this issue myself.

    • Debra says:

      I was diagnosed with a ET- a Myleoproliferative Neoplasm– a rare type of blood cancer and have recently connected it with my TVT. This cause high platelet counts which occured within the first two years after implantation of the sling

      I have been walking around in a brain fog due to poor circulation & very sensitive to smells and chemicals

      If you have not checked out your blood work, I would recommend seeing a hematologist for a possible gene mutation.

      I am definitely getting this out of my body!

      THIS CONCERNS ME!!! Why are all of these women complaining about automimmunes and other serious issues and no one seems to care!!!

      • Jane Akre says:

        Debra- Agreed. Could you please forward me the contact person you used to connect the dots with your mesh sling. Thank you. janeakre@meshnewsdesk.com Almost 2/3rds of women I talk to and even some hernia folks, have autoimmune issues, yet that is not ever being raised at trial! not yet because the science isn’t there…..I’m told.

  24. Nicki says:

    Jane,

    Thank you for putting this info out here for all to read. I’m devastated to say the least, 1994 I had a hyst and bladder sling procedure done as well as abnormal tissue removed, yes all of the above list has been my life in a nut shell. Pain, autoimmune problems etc. back pain severe but still able to live a reasonable life, unbearable symtoms started Nov 2013. New to Azizonia found a good Internal Doctor. Referred me to gynecologist which exam me an said sling in very thight and referred me to a urologist did testing but not the cystoscope, Refered to have a upper and lower Colonoscopy, second in 3 yrs. same result a few polyps removed, Diverticulitis, Back, abdominal pain and inability to void, increased pain back and abdominal pain intensifying , Feeling desperate for relieve and answers to what is going on, doctor referred me to a pain doctor and had lumbar injections, an 2 nerve blocks that has left me bedridden an almost no ability to urinate, weakest in legs low grade fevers the smell of urine from urethra and feeling sick and lost without answers, Iternal medicine doctor did more labs no infections but sent me back to another urologist, I was cathetered to give urine sample and samples sent to culture for cancer type cells and next week 2 procedures one of which a cystoscope be preformed, Urologist did talk to me a lot about bladder sling and did inform me of complex complicated this is! I am unable to void an in severe discomfort, I am hoping to understand more of what type of procedures are done to remove or correct this, what should I except. Needless to say I have not left a rock unturned but still living bedridden and no real answers. Helpless but no Hopless

  25. julie says:

    Contact for herbal cure.. Very effective! I want to share my review on Dr Mutuma.. I was diagnosed of motor neuron disease (Gehrig’s disease) in 2011 and I have tried all I can to get cured but all to no avail, my life was gradually coming to an end, until i saw some reviews in a health forum about a herbal doctor called Dr Mutuma from Israel (jerusalem) who cures motor neuron disease with herbal medicine and all kind of diseases including diabetes, kidney problem, Leukemia, Asthma, Gonorrhea etc, at first i doubted if it was real but I decided to give it a try, when i contacted this herbal doctor via his email, he asked me to fill the form and I followed all the instruction. He prepared a herbal medicine portion and sent it to me via courier service, when i received this herbal medicine portion, he gave me descriptions on how to use it and I followed it. Am using it as instructed, i was cured of this deadly disease within 3weeks, I could not walk or talk understandably before but after i took the herbal cure as he instructed i regained strength in my bones and i could talk properly unlike before, I am now free from the deadly disease, all thanks to Dr Mutuma. Contact this great herbal doctor via his email drmutumahouseofsolution121 @ gmail . com “He can cure any kinds of disease or sickness with herbal medicine” you have my word.

  26. james Hill says:

    I had bi lateral hernia repair in 2005 and have been in pain ever since, just recently test have shown my colon is inflamed snd swollen, also my now 12 year old son had hernia repair at the age of 3,few years later he got diagnosis of Chrons, I’m starting to question whether or not the mesh implants has caused us this painful and life changing circumstances, if you know of anyone who could help us get answers please contact me

    Thanks James Hill

    • Jane Akre says:

      Contact Bruce Rosenberg 954-701-5094 about all things hernia mesh related…. he has a nonprofit dedicated to patient education.

  27. Kitty says:

    Jane. Just a simple *thank you”for bringing Ms Wideman’s research article back. It is really distressing to realize the damage that has been done. It is a cancer…if you will…in the field of medicine

  28. TStephens says:

    My wife had a mesh placed in the early 2000’s with severe complications including a massive infection that took nearly three weeks of daily infusions of Vancomycin and Gentamicin to clear the infection. Fast forward about 10-12 years and she developed all kinds of health issues that I kept telling physician after physician all had to be linked together. She was diagnosed in October of 2013 with Vasculitis which causes inflammation in the blood vessels. This is an autoimmune disorder that is very rare. Her particular form of this deadly and rare disease is called Polyarteritis Nodosa (PAN, for short) . Her PAN doctor at the University of North Carolina linked the disease onset with a severe infection which was the likely the root cause of the PAN.

    He has documented this in a court affidavit for our case against JnJ. The attorney’s have told us this will be a huge factor in her case! From my research there are at least 5 known cases of vasculitis development as a result of a mesh being placed. JnJ should be brought down for what the are doing to people… a company that was allegedly built upon being ethical has completely lost their way and have been ALL about profits at the expense of safe and efficacious products.

    • Jane Akre says:

      I wish you well in your case. What is needed is research and some answers into the horrendous autoimmune issues that arise in some patients with a polypropylene implant. I hope your law firm will take that to a jury! Thank for writing and I’m sorry.

  29. Mary M. says:

    I have had many surgeries since 2005-2009 for eroded pelvic mesh into the uretha, bladder and then again in 2012, 2013 for erosion into the vagina. On July 6, 2015, I had a terrible pain in my right side and through the vaginal right side. The pain then spread through the pelvic region along with the area becoming red and warm. I had to
    urinate and passed two, tiny blood clots vaginally. I found a reacher and took the pieces from the toilet, placed them on a piece of gauze. I realized they appeared to be mesh. I was able to get in to see my GYNE the next day but he didn’t think it was mesh. Another no-nothing doctor. I should have taken a picture as the tiny pieces eventually disappeared. However, those pieces were coming from the Obtruator area where the TOTs are anchored. I ended up calling 911 and was in two hospitals for over 12 days and required surgery. The broken mesh had caused cellulitis in that area which then resulted in sepsis. I almost died. The surgeon removed over a liter of purulent fluid from the area and I had to wear penrose drains for a few months after that. Since that implant in 2005 and the consequence surgeries that followed, I have supposedly developed an allergic asthma that seems to result from GERD, which I don’t have. I have also developed muscle aches, had a stress fracture occur in my foot while driving, have constant tendonitis. I’ve only seen my ortho doc for a bad shoulder, the broken foot, a hand injury, a knee injury, now Plantar Faciitis that don’t show any bone problems on the X-rays. but my doctors don’t order MRIS to see the tissues and ligaments. I can almost guarantee these injuries are due to the mesh affecting my immune system.Unfortunately, the docs don’t want to connect one to the other but they’re not just coincidence. I read here that Dr. Rosenberg contributes to this website. He is affiliated with the last hospital I was in for the orbturator mesh mess. I am going to try and get an appointment with a rheumatologist there to see if Dr. Rosenberg can possibly get a clinical trial/survey of the correlations between the mesh and autoimmune diseases. Since it’s Chicago, we could possibly get it on one of the major news channels here but it’s going to take time. Stay tuned.

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